NCGC Bioinformatics team participates in ICGC mutation calling benchmark study

Our Bioinformatics team worked with some of the best teams internationally to improve the complex task of making reliable and reproducible algorithms to score tumour mutations. The results are published in Nature Communications.

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Database of Norwegian normal variation

We have extracted all single nucleotide variation in normal samples from our patients, and make their frequencies available at our web site

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Precision medicine for the individual

Personalized medicine or precision medicine is a term for a set of diagnostic methods that seek to find the treatment that is tailored to each individual - mainly genetic - properties. It is the rapid development of analysis of the genetic material that gives hope for better and more accurate treatment of cancer patients. In case of cancer, where both hereditary traits and mutations that occur in cancer cells may be important for treatment, personalized medicine could save more lives and give cancer patients a longer life with the disease. Furthermore, one could protect more people from unnecessary treatment and the ailments from this. We all have a unique combination of genetic variants of genes that affect how the body processes and responds to cancer treatment and the central and side effects we might get it. These differences also affect how the individual tumor responds to treatment.

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What is personalized cancer treatment?

Cancer is an extremely complex disease, and we traditionally categorize cancers with names indicative of the tissue the cancer is situated in, or alternatively is similar to (e.g. breast cancer, colon cancer, lung cancer, etc.) However, a tumour classed within one cancer group (e.g. lung cancer) can often be very different from another lung cancer tumour. Instead, tumours can share genetic similarities with tumours classed in other cancer groups.

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Kreft er komplekst

Kreftsykdommene er uhyre komplekse, og selv om vi tradisjonelt kategoriserer kreftformene med navn som indikerer hvilket vev de oppstår i eller ligner på, for eksempel brystkreft, tarmkreft, lungekreft osv., er det store forskjeller mellom både pasientene og kreftsvulstene innenfor hver gruppe, men også likheter på tvers av gruppene.

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Vellykket NCGC-symposium på Losby Gods

Alle forskere og stipendiater i NCGC var samlet for å utveksle metoder og resultater under et todagers symposium på Losby Gods i slutten av oktober 2015. Du kan her se temaene som ble presentert og kontaktinformasjon for de ansvarlig forskere. Ta gjerne kontakt hvis du er interessert i samarbeid!

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